Re: R6 2000
Easy yes. But a lot needs to come apart first to get access. I am not familiar with the 2000 so I don't know what kind of clearances there is upfront. So everything I am about to say is related to my experience with a 2007. There are 2 ways to go about it.
The first way and the most frustrating is going through the air box. It requires removing the airbox and whatever else is in the way. The fit is tight and I can never get tools in there to comfortably do the job right, hence the frustration.
The way I prefer is removing the radiator. It requires draining the coolant, but this is a good time to change the coolant if it's been awhile. Then do whatever is required to get the radiator out (pretty straight forward, just loosening some hose clamps etc.). But when you go this route the rest of the job is stress-free as you have clear access to the coils and plugs. Then just reverse the process and refill the radiator.
Just don't make the mistake of over tightening the spark plugs. For new plugs, I tighten by hand then do a half-turn with a wrench. Make sure you have a decent spark plug socket. I like the ones with the extension on a ball socket so I am not accidentally applying angular force to the plug. And a magnetic socket makes life easier as well.
Check youtube for some videos if you need to. The service manual if needed, and you don't already have, can be downloaded from r6messagenet.