I'm assuming your going to do so for drag racing. Methanol is an awesome fuel to make some impressive HP #'s from.
A little more info for what your going to or plan on running it for will help. But I would start with doing some porting, either shaving the head or using a smaller gasket, running some fairly long duration cam set-ups, and most likely running a little hotter plug (but you'll wanna trial and error til you work with hotter plugs..
Base line, you'll wanna start basically doubling the amount of fuel. Double main jets, raise the needle, open fuel screws. Can be a big pain in the ass dialing in jetting, but it is very important with methanol.
And if you have experience with methanol, you know you should basically run the whole fuel system dry of the fuel when not running or used....it LOVES to eat aluminum and especially fuel lines.
Also know that if you are running temperatures below 60 degrees or so is going to require alternate fuel for getting the engine started easily.
Also, start with timing curve stock, get jetting figured out, then you will know how rich or lean you are in places and how much room you have, then you can start playing with timing.......which advancing with methanol will give signifcant gains.