Yeah, i just spent 2 days last week figuring out adjustments on a dyno with the PC. Understand how to do it and such, but I still have alot to learn with it. I've also have lots of tuning experience with carbs and such, so that really helps.
I think the best way to tune is by checking the plugs and using EGT's (exhaust gas temps) like mentioned above. A exhaust gas analyzer is a good way to do it and more logical cause checking plugs in incriments in 250 rpms and 9 different throttle positions all the way to 16,000 rpms just isnt gonna happen. So a analyzer will make it alot quicker.
The best way is to use plug readings in direct relation to EGT's. Find a good plug reading, match it to the EGT. Then you know what your plugs are looking like with that exhaust temp #.
A PC is a good thing to have, but I don't recommed doing adjustments without some experience. From my experience, it is physically easier than jetting carbs, but the whole tuning process is alot harder!!